Rethinking Pseudo-LiDAR Representation

The recently proposed pseudo-LiDAR based 3D detectors greatly improve the benchmark of monocular/stereo 3D detection task. However, the underlying mechanism remains obscure to the research community. In this paper, we perform an in-depth investigation and observe that the efficacy of pseudo-LiDAR representation comes from the coordinate transformation, instead of data representation itself. Based on this observation, we design an image based CNN detector named Patch-Net, which is more generalized and can be instantiated as pseudo-LiDAR based 3D detectors. Moreover, the pseudo-LiDAR data in our PatchNet is organized as the image representation, which means existing 2D CNN designs can be easily utilized for extracting deep features from input data and boosting 3D detection performance. We conduct extensive experiments on the challenging KITTI dataset, where the proposed PatchNet outperforms all existing pseudo-LiDAR based counterparts. Code has been made available at: https://github.com/xinzhuma/patchnet.Comment: ECCV2020. Supplemental Material attache

Transcriptional up-regulation of relaxin-3 by Nur77 attenuates β-adrenergic agonist-induced apoptosis in cardiomyocytes.

The relaxin family peptides have been shown to exert several beneficial effects on the heart, including anti-apoptosis, anti-fibrosis, and anti-hypertrophy activity. Understanding their regulation might provide new opportunities for therapeutic interventions, but the molecular mechanism(s) coordinating relaxin expression in the heart remain largely obscured. Previous work demonstrated a role for the orphan nuclear receptor Nur77 in regulating cardiomyocyte apoptosis. We therefore investigated Nur77 in the hopes of identifying novel relaxin regulators. Quantitative real-time PCR (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) data indicated that ectopic expression of orphan nuclear receptor Nur77 markedly increased the expression of latexin-3 (RLN3), but not relaxin-1 (RLN1), in neonatal rat ventricular cardiomyocytes (NRVMs). Furthermore, we found that the -adrenergic agonist isoproterenol (ISO) markedly stimulated RLN3 expression, and this stimulation was significantly attenuated in Nur77 knockdown cardiomyocytes and Nur77 knockout hearts. We showed that Nur77 significantly increased RLN3 promoter activity via specific binding to the RLN3 promoter, as demonstrated by electrophoretic mobility shift assay (EMSA) and chromatin immuno-precipitation (ChIP) assays. Furthermore, we found that Nur77 overexpression potently inhibited ISO-induced cardiomyocyte apoptosis, whereas this protective effect was significantly attenuated in RLN3 knockdown cardiomyocytes, suggesting that Nur77-induced RLN3 expression is an important mediator for the suppression of cardiomyocyte apoptosis. These findings show that Nur77 regulates RLN3 expression, therefore suppressing apoptosis in the heart, and suggest that activation of Nur77 may represent a useful therapeutic strategy for inhibition of cardiac fibrosis and heart failure. © 2018 You et al

GUPNet++: Geometry Uncertainty Propagation Network for Monocular 3D Object Detection

Geometry plays a significant role in monocular 3D object detection. It can be used to estimate object depth by using the perspective projection between object's physical size and 2D projection in the image plane, which can introduce mathematical priors into deep models. However, this projection process also introduces error amplification, where the error of the estimated height is amplified and reflected into the projected depth. It leads to unreliable depth inferences and also impairs training stability. To tackle this problem, we propose a novel Geometry Uncertainty Propagation Network (GUPNet++) by modeling geometry projection in a probabilistic manner. This ensures depth predictions are well-bounded and associated with a reasonable uncertainty. The significance of introducing such geometric uncertainty is two-fold: (1). It models the uncertainty propagation relationship of the geometry projection during training, improving the stability and efficiency of the end-to-end model learning. (2). It can be derived to a highly reliable confidence to indicate the quality of the 3D detection result, enabling more reliable detection inference. Experiments show that the proposed approach not only obtains (state-of-the-art) SOTA performance in image-based monocular 3D detection but also demonstrates superiority in efficacy with a simplified framework.Comment: 18 pages, 9 figure

Investigation of Humidity and Temperature Response of a Silica Gel Coated Microfiber Coupler

The humidity and temperature responses of a microfiber coupler (MFC) coated with silica gel are investigated. Two MFC structures with different waist diameters of 2.5 and 3.5 μm were fabricated by fusing and tapering two single-mode fibers using a microheater brushing technique. The influences of the coating thickness and tapered waist diameter on the sensing performance are analyzed. For the proposed sensor with a waist diameter of 2.5 μm and 8-layers thick coating, the change in the relative humidity (RH) results in an exponential blueshift with a maximum sensitivity of 1.6 nm/% RH in the range from 70 to 86% RH. In response to the temperature change, the sensor's transmission spectrum redshifts in a linear fashion with an average sensitivity of 0.55 nm/°C in the range from 20 to 40 °C. The study is important for the development of the proposed fiber structure as a humidity or temperature sensor

High sensitivity ammonia gas sensor based on a silica gel coated microfiber coupler

In this paper, a high sensitivity ammonia gas sensor is proposed based on a silica gel coated microfiber coupler (MFC). The MFC structure is formed by the two tapered fibers with 3 μm waist diameter each, which were fabricated by using a customized microheater brushing technique. Silica gel coating was prepared by a sol-gel technique and applied on the surface of the MFC as a thin layer. The spectral characteristics of the proposed sensor were studied under various ammonia gas concentrations. The experimental results show that the coating thickness strongly affected the sensitivity of the MFC-based sensor to ammonia gas concentration. For the sensor with a 90 nm silica gel coating thickness, the highest measurement sensitivity is 2.23 nm/ppm for ammonia gas concentration, and the resolution is as good as 5 ppb, while the measured response and recovery times are ~ 50 and 35 seconds, respectively. Finally, it is demonstrated that the proposed sensor offers good repeatability and selectivity to ammonia gas

A Label-Free Fiber Ring Laser Biosensor For Ultrahigh Sensitivity Detection of Salmonella Typhimurium

The rapid detection of low concentrations of Salmonella Typhimurium (S. Typhimurium) is an essential preventive measure for food safety and prevention of foodborne illness. The study presented in this paper addresses this critical issue by proposing a single mode-tapered seven core-single mode (STSS) fiber ring laser (FRL) biosensor for S. Typhimurium detection. The experimental results show that the specific detection time of S. Typhimurium is less than 20 min and the wavelength shift can achieve -0.906 nm for an S. Typhimurium solution (10 cells/mL). Furthermore, at a lower concentration of 1 cell/mL applied to the biosensor, a result of -0.183 nm is observed in 9% of samples (1/11), which indicates that the proposed FRL biosensor has the ability to detect 1 cell/mL of S. Typhimurium. In addition, the detection results in chicken and pickled pork samples present an average deviation of -27% and -23%, respectively, from the measured results in phosphate buffered saline. Taken together, these results show the proposed FRL biosensor may have potential applications in the fields of food safety monitoring, medical diagnostics, etc

Microdisk Resonator With Negative Thermal Optical Coefficient Polymer for Refractive Index Sensing With Thermal Stability

In this paper, we propose a microdisk resonator with negative thermal optical coefficient (TOC) polymer for refractive index (RI) sensing with thermal stability. The transmission characteristics and sensing performances by using quasi-TE01 and quasi-TM01 modes are simulated by a three-dimensional finite element method. The influences of the TOC, RI, and thickness of the polymer on the sensing performances are also investigated. The simulation results show that the RI sensitivity Sn and temperature sensitivity ST with different polymers are in the ranges of 25.1-26 nm/RIU and 67.3-75.2 pm/K for the quasi-TE01 mode, and 94.5-110.6 nm/RIU and 1.2-51.3 pm/K for the quasi-TM01 mode, respectively. Moreover, figure-of-merit of the temperature sensing for the quasi-TM01 mode is in the range of 2 × 10-4-8 × 10-3, which can find important application in the implementation of the adiabatic devices

Microdisk Resonator With Negative Thermal Optical Coefficient Polymer for Refractive Index Sensing With Thermal Stability

In this paper, we propose a microdisk resonator with negative thermal optical coefficient (TOC) polymer for refractive index (RI) sensing with thermal stability. The transmission characteristics and sensing performances by using quasi-TE01 and quasi-TM01 modes are simulated by a three-dimensional finite element method. The influences of the TOC, RI, and thickness of the polymer on the sensing performances are also investigated. The simulation results show that the RI sensitivity Sn and temperature sensitivity ST with different polymers are in the ranges of 25.1-26 nm/RIU and 67.3-75.2 pm/K for the quasi-TE01 mode, and 94.5-110.6 nm/RIU and 1.2-51.3 pm/K for the quasi-TM01 mode, respectively. Moreover, figure-of-merit of the temperature sensing for the quasi-TM01 mode is in the range of 2 × 10 -4 -8 × 10 -3 , which can find important application in the implementation of the adiabatic devices

Vitrectomy using 0.025% povidone-iodine irrigation for treating post-traumatic endophthalmitis due to intraocular foreign bodies: Two case reports

Traumatic eye injury-related endophthalmitis is a serious traumatic complication that threatens the vision of many patients worldwide. Herein, we present two cases of traumatic endophthalmitis that underwent 0.025% povidone-iodine treatment and hoped to introduce the bactericidal effect of 0.025% povidone-iodine in balanced salt solution PLUS (0.025% PI-BSS PLUS) and its use in vitrectomy for traumatic endophthalmitis. The 0.025% PI-BSS PLUS solution is bactericidal and nontoxic when used as an irrigation solution in pars plana vitrectomy. The two cases of traumatic endophthalmitis were resolved by pars plana vitrectomy using 0.025% PI-BSS PLUS